My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format

Send to:

Choose Destination
  • Your browser version may not work well with NCBI's Web applications. More information here...

EMBO J. 1998 Nov 16;17(22):6527-40.

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A.

Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA.

The GTPases Rac and Cdc42Hs control diverse cellular functions. In addition to being mediators of intracellular signaling cascades, they have important roles in cell morphogenesis and mitogenesis. We have identified a novel PAK-related kinase, PAK4, as a new effector molecule for Cdc42Hs. PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain (GBD). Co-expression of PAK4 and the constitutively active Cdc42HsV12 causes the redistribution of PAK4 to the brefeldin A-sensitive compartment of the Golgi membrane and the subsequent induction of filopodia and actin polymerization. Importantly, the reorganization of the actin cytoskeleton is dependent on PAK4 kinase activity and on its interaction with Cdc42Hs. Thus, unlike other members of the PAK family, PAK4 provides a novel link between Cdc42Hs and the actin cytoskeleton. The cellular locations of PAK4 and Cdc42Hs suggest a role for the Golgi in cell morphogenesis.

PMID: 9822598 [PubMed - indexed for MEDLINE]

PMCID: 1171000

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types:

MeSH Terms:

Substances:

Secondary Source ID:

LinkOut - more resources

Full Text Sources:

Other Literature Sources:

Supplemental Content

Click here to read Click here to read

Related articles

Cited by 27 PubMed Central articles

All links from this record

  • Related Articles

    Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.

  • Compound (MeSH Keyword)

    PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

  • Gene

    Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.

  • Gene (GeneRIF)

    Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.

  • Gene (OMIM)

    Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.

  • HomoloGene

    HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.

  • Nucleotide

    Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.

  • Nucleotide (RefSeq)

    NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.

  • Nucleotide (Weighted)

    Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.

  • OMIM (calculated)

    Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.

  • OMIM (cited)

    Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.

  • Protein (RefSeq)

    NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.

  • Protein (Weighted)

    Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.

  • References for this PMC Article

    Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.

  • Substance (MeSH Keyword)

    PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

  • Taxonomy via GenBank

    Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).

  • UniGene

    UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.

  • Protein

    Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.

  • GEO Profiles

    Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.

  • Free in PMC

    Free full text articles in PMC

  • Cited in PMC

    Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity