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Biotechniques. 1998 Nov;25(5):886-90.

Parallel production of oligonucleotide arrays using membranes and reagent jet printing.

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  • 1Barclay College, Haviland, KS, USA.


Here, we present a low-cost method to produce compact arrays using microporous materials and reagent jetting. Oligonucleotides are immobilized on membrane sheets as a series of lines. The membrane sheet is then rolled and bound, and the spiral structure is cut like a "jelly roll" to produce identical arrays. The spiral arrays behave much like larger formats using membranes, and hybridization detection can be accomplished using standard signal-generation mechanisms. The method is particularly useful for producing identical arrays from pre-synthesized oligonucleotides.

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