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Curr Opin Chem Biol. 1998 Oct;2(5):633-41.

Protein tyrosine phosphatases: mechanisms of catalysis and regulation.

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  • 1Oregon Health Sciences University, Department of Biochemistry and Molecular Biology, Portland 97201-3098, USA.


Recent structural information suggests that the HC(X)5R active-site motif defines three distinct evolutionary families of phosphatases that employ a common catalytic mechanism. In two instances, regulation of phosphatase activity employs autoinhibitory mechanisms involving either intermolecular or intramolecular interactions, whereby inhibition is mediated by sterically blocking the active-site cleft.

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