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Curr Opin Cell Biol. 1998 Oct;10(5):609-13.

DCC and netrins.

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  • 1Department of Molecular and Medical Genetics, Faculty of Medicine, University of Toronto, Canada.


Recent advances highlight the versatility and complexity of this highly conserved axon and cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly and mouse all suggest that netrins play local as well as long-range roles in guidance. Evidence from multiple sources also indicates that the netrin receptor DCC can mediate both attractive and repulsive responses to netrins.

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