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Structure. 1998 Nov 15;6(11):1345-50.

Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes.

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  • 1European Molecular Biology Laboratory Postfach, 10.2209 D-69012 Heidelberg, Germany.

Abstract

Coenzyme A (CoA) is well known for its importance in various metabolic pathways. The recent determination of the structures of several CoA-dependent N-acylating enzymes highlights the importance of the acyl-CoA molecule for intracellular regulation and reveals a novel fold. The N-acetyltransferase fold defines yet another protein superfamily and adds to the already diverse world of CoA-dependent enzymes.

PMID:
9817851
[PubMed - indexed for MEDLINE]
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