Umbilical blood lead level, as an indicator for intrauterine exposure to lead, and neurobehavioral score, as an effect indicator, were determined in 101 neonates in Beijing area to explore the relationship between intrauterine lead exposure and neonatal neurobehavioral development. Results revealed that there was a negative relationship between neonatal umbilical blood lead level and their neurobehavioral score and behavioral ability. With umbilical blood lead level of 0.48 mumol/L as a cutoff value, there was a significant difference in neonatal behavioral ability score between groups of high and low blood lead levels. There also were significant differences in nonbiologically auditory and biological visual and auditory orientation reaction. It suggests that intrauterine lead exposure can cause adverse effects on neonatal neurobehavioral development, especially on their visual and auditory function.