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Mol Immunol. 1998 Jun;35(9):559-63.

Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking.

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  • 1Center for BioMedical Science, School of Medicine, Chiba University and CREST of the Japan Science and Technology Corporation.

Abstract

Polycomb group (PcG) genes were initially described in Drosophila melanogaster as regulators of the homeobox gene. Four mammalian homologues, mel-18, bmi-1, M33 and rae-28, are analyzed in this study. They not only regulate mammalian homeotic genes by analogy with their Drosophila counterparts, but also have some influence on the growth and differentiation of B lymphocytes. Here we report that these four mammalian PcG genes are rapidly induced after antigen-receptor cross-linking in B cells. Thus we would like to propose that mammalian PcG genes can be categorized as a new type of immediate early gene.

PMID:
9809583
[PubMed - indexed for MEDLINE]
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