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J Neurol. 1998 Nov;245(11):695-708.

Neurological complications of radiotherapy and chemotherapy.

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  • 1Service de Neurologie, Hôpital de la Salpetrière, Paris, France.


Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.

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