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Trends Microbiol. 1998 Oct;6(10):392-401.

The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages.

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  • 1Dépt de Physiopathologie, Institut Pasteur, Paris, France. jantoine@pasteur.fr


Leishmania are protozoan parasites that, as amastigotes, live in the macrophages of mammalian hosts within compartments called parasitophorous vacuoles. These organelles share features with late endosomes/lysosomes and are also involved in the trafficking of several major histocompatibility complex (MHC)-encoded molecules. Improved knowledge of the parasitophorous vacuoles may help clarify how these protozoa persist in their hosts.

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