Abstract
Antigenic differences between the two major groups of respiratory syncytial (RS) virus may contribute to reinfections with these viruses. Additional variability occurs within the two major groups; the importance of intra-group variability in reinfections with RS virus has not been defined. Two pairs of group A viruses that had caused sequential infections in children showed G protein amino acid differences of up to 15%. Vaccinia viruses were constructed that expressed the G proteins from 2 of the paired group A isolates. Immunization of cotton rats with the recombinant vaccinia viruses provided equal protection against intranasal challenge by either of the RS viruses. Despite the amino acid differences between the two group A RS virus G proteins, these animal studies did not reveal differences in protection after immunization with the two G proteins. Precise definition of the role of RS virus antigenic variability in the establishment of reinfections in humans will require further investigations in humans.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigenic Variation
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Antigens, Viral / genetics*
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Antigens, Viral / immunology
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Child, Preschool
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Female
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Genetic Variation
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HN Protein*
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Humans
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Infant
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / immunology
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Recurrence
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Respiratory Syncytial Virus Infections / immunology
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Respiratory Syncytial Virus Infections / virology*
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Respiratory Syncytial Virus, Human / classification
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Respiratory Syncytial Virus, Human / genetics*
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Respiratory Syncytial Virus, Human / immunology
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Sequence Homology, Amino Acid
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Sigmodontinae
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Vaccination
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Vaccinia virus / genetics
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Viral Envelope Proteins
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Viral Proteins / biosynthesis
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Viral Proteins / genetics*
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Viral Proteins / immunology
Substances
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Antigens, Viral
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HN Protein
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Recombinant Proteins
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Viral Envelope Proteins
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Viral Proteins
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attachment protein G
Associated data
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GENBANK/AF065405
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GENBANK/AF065406
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GENBANK/AF065407
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GENBANK/AF065408
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GENBANK/AF065409
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GENBANK/AF065410