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Biochim Biophys Acta. 1998 Nov 8;1442(2-3):329-33.

Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.

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  • 1Department of Haematology, Institute of Clinical Science, The Queen's University of Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UK.

Abstract

Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.

PMID:
9804983
[PubMed - indexed for MEDLINE]
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