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Science. 1998 Nov 6;282(5391):1126-32.

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.

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  • 1Institute for Genomic Research, Rockville, MD 20850, USA.

Erratum in

  • Science 1998 Dec 4;282(5395):1827.

Abstract

Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

PMID:
9804551
[PubMed - indexed for MEDLINE]
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