Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nucl Med Biol. 1998 Oct;25(7):599-603.

2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors.

Author information

  • 1Brain Imaging Center, Intramural Research Program, NIDA, Baltimore, MD 21224, USA.

Abstract

The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAChR selective ligands as well as with unlabeled 2-fluoro-A-85380. A preliminary toxicology study of the 2-fluoro-A-85380 showed a relatively low biological effect. 2-[18F]Fluoro-A-85380 holds promise as a useful radiotracer for imaging of nAChRs with PET.

PMID:
9804040
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk