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Regul Pept. 1998 Sep 25;75-76:433-9.

Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice.

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  • 1Department of Metabolic Diseases, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. francoise_j.smith@roche.com


OB protein (or leptin) administration causes a long-lasting reduction in food intake and body weight in obese ob/ob mice. Neuropeptide Y, a stimulator of feeding, has been proposed to be a major mediator of the biological actions of OB protein. To test this hypothesis, the interaction of brain administration of exogenous OB protein and NPY on the feeding behavior of ob/ob mice was examined. Human OB protein, in a dose-dependent manner, partially or completely blocked feeding induced by exogenous NPY. These results demonstrate that OB protein can functionally antagonize and dominate the actions of exogenous NPY on feeding.

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