Metastasizing pleomorphic adenoma: a report of three cases

Eur J Surg Oncol. 1998 Oct;24(5):452-5. doi: 10.1016/s0748-7983(98)92651-8.

Abstract

Three cases of metastasizing pleomorphic adenoma are described. All three had a history of incomplete surgery of the primary tumour and several surgical procedures for local recurrences before systemic metastases became apparent. The histology of the primary tumour, recurrences and metastases were typical of pleomorphic adenoma. In view of the lack of information in the literature, it is concluded that inadequate surgical procedures, such as incomplete surgery or enucleation, leading to multiple recurrences, appear to be a prerequisite for the development of systemic disease.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Pleomorphic / pathology*
  • Adenoma, Pleomorphic / surgery*
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Parotid Neoplasms / pathology
  • Parotid Neoplasms / surgery
  • Reoperation
  • Salivary Gland Neoplasms / pathology*
  • Salivary Gland Neoplasms / surgery*
  • Submandibular Gland Neoplasms / pathology
  • Submandibular Gland Neoplasms / surgery