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    Jpn J Clin Oncol. 1998 Sep;28(9):563-6.

    Undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy.

    Kakizaki S, Ohya N, Yoshinaga T, Higuchi T, Kitazawa R, Takayama H, Takagi H, Nagamine T, Mori M.

    Source

    Department of Internal medicine, Saiseikai Maebashi Hospital, Japan. kakizaki@news.sb.gunma-u.ac.jp

    Abstract

    We present a case of undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) is identified as the causative factor of hypercalcemia. A 61-year-old man was hospitalized with right hypochondralgia. Ultrasound examination and computed tomography demonstrated a large mass in the pancreatic head with liver metastases. Biopsy of the pancreatic tumor demonstrated undifferentiated carcinoma. Serum calcium level and PTH-rP were elevated. Bone scan with technetium-99 demonstrated no accumulation in the bones. Immunohistochemical staining for PTH-rP was weakly positive in the tumor cells. We considered that PTH-rP was the causative factor of HHM in this case from laboratory data and immunohistochemical findings. This rare case was successfully treated with pamidronate disodium, which is a type of bisphosphonate derivative. We compared this case with previously reported cases.

    PMID:
    9793031
    [PubMed - indexed for MEDLINE]
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