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Chest. 1998 Oct;114(4):998-1007.

Integrating patient preferences into health outcomes assessment: the multiattribute Asthma Symptom Utility Index.

Author information

  • 1MEDTAP International, Inc, Bethesda, MD 20814, USA. Revicki@Medtap.com

Abstract

STUDY OBJECTIVE:

To develop and evaluate a brief, easy-to-administer symptom assessment scale for use as a preference-based outcome measure in clinical trials and cost-effectiveness studies in asthma.

DESIGN:

Cross-sectional survey with 2-week reproducibility assessment.

SETTING:

Ambulatory care: university asthma and allergy center.

PARTICIPANTS:

One hundred sixty-one adults with asthma, 59% female, mean age 35+/-11 years. Mean FEV1 percent predicted was 86+/-17%.

INTERVENTIONS:

The 11-item Asthma Symptom Utility Index (ASUI).

MEASUREMENTS AND RESULTS:

Mean ASUI score for this sample was 0.71+/-0.23, with a range from 0.02 to 1.0. The ASUI was reproducible (intraclass correlation coefficient = 0.74) and able to distinguish patients known to differ on disease severity according to clinician ratings (p < 0.001) and by an asthma disease severity scale score (p < 0.001). The instrument was also significantly correlated with FEV1 percent predicted (r = 0.27, p < 0.001), the Asthma Quality of Life Questionnaire (r = 0.77, p < 0.001), and the Health Utilities Index Mark 2 (r = 0.36, p < 0.001).

CONCLUSION:

The results of this study support the reliability and validity of the ASUI, suggesting it will be a useful, complementary patient outcome measure for clinical trials and cost-effectiveness studies comparing treatment alternatives for persons with asthma.

PMID:
9792568
[PubMed - indexed for MEDLINE]
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