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Am J Physiol. 1998 Nov;275(5 Pt 2):R1399-411.

Innervation of mammalian white adipose tissue: implications for the regulation of total body fat.

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  • 1Departments of Psychology, and of Biology, Neuropsychology and Behavioral Neurosciences, Georgia State University, Atlanta, Georgia 30303, USA.

Abstract

We review the extensive physiological and neuroanatomical evidence for the innervation of white adipose tissue (WAT) by the sympathetic nervous system (SNS) as well as what is known about the sensory innervation of this tissue. The SNS innervation of WAT appears to be a part of the general SNS outflow from the central nervous system, consisting of structures and connections throughout the neural axis. The innervation of WAT by the SNS could play a role in the regulation of total body fat in general, most likely plays an important role in regional differences in lipid mobilization specifically, and may have a trophic affect on WAT. The exact nature of the SNS innervation of WAT is not known but it may involve contact with adipocytes and/or their associated vasculature. We hypothesize that the SNS innervation of WAT is an important contributor to the apparent "regulation" of total body fat.

PMID:
9791054
[PubMed - indexed for MEDLINE]
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