Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1998 Sep;23(9):324-8.

Conservation of gene order: a fingerprint of proteins that physically interact.

Author information

  • 1European Molecular Biology Laboratory, Heidelberg, Germany.


A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk