Eye (Lond). 1998;12 ( Pt 3b):499-503.

The retinal pigment epithelium as a developmental regulator of the neural retina.

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Institute of Ophthalmology, UCL, London, UK. g.jeffery@ucl.ac.uk

Abstract

Melanin-related agents regulate the development of the mammalian neural retina, because in albinos there are a range of retinal deficits including abnormal connections between the eye and brain, an underdeveloped central retina and a rod deficit. These deficits may arise because gradients of retinal development in the albino are delayed and the retina is abnormally proliferative, but also goes through a subsequent period of excessive cell death. This may be caused by a reduction in ocular DOPA in albinos as this is in the synthetic pathway of melanin and is a known cell cycle regulator.

PMID:: 9775209; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

L-DOPA is an endogenous ligand for OA1. [PLoS Biol. 2008]
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In vivo gene delivery in the retina using polyethylenimine. [Biotechniques. 2007]
In vivo gene delivery in the retina using polyethylenimine.
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