Strategy for lipid suppression in lactate imaging using STIR-DQCT: a study of hypoxic-ischemic brain injury

Magn Reson Med. 1998 Oct;40(4):629-32. doi: 10.1002/mrm.1910400416.

Abstract

In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short-time-inversion-recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit model of hypoxic and unilateral-ischemic brain injury showed reduction down to 29 +/- 11% in lipids with inversion times between 140 and 170 ms. Lactate signals on the ischemic side were 51 +/- 53% higher than the nonischemic side at the peak of hypoxia. STIR-DQCT can be a useful robust method of obtaining metabolic maps of lactate in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain Ischemia / metabolism*
  • Hypoxia, Brain / metabolism*
  • Image Enhancement / methods
  • Lactic Acid / metabolism*
  • Magnetic Resonance Spectroscopy* / methods
  • Phantoms, Imaging
  • Rabbits

Substances

  • Lactic Acid