Send to:

Choose Destination
See comment in PubMed Commons below
Int Rev Cytol. 1999;186:225-60.

Hepatocyte growth factor and the kidney: it is not just for the liver.

Author information

  • 1Department of Medicine, University of Alabama at Birmingham, USA.


Mesenchymal-epithelial interactions are important for many biological processes in epithelial organs such as the kidney. Hepatocyte growth factor (HGF) is a mesenchymally derived polypeptide cytokine that acts through its tyrosine kinase c-met receptor and is an important mediator of these interactions. This article reviews data showing the in vitro actions of HGF on renal epithelial cells that result in such diverse responses as mitogenesis, motogenesis, and morphogenesis. It also examines the in vivo evidence linking HGF and the c-met receptor to kidney development, regeneration following injury, and renal disease. Elucidating cellular mechanisms underlying the coordinated control of diverse HGF-induced phenotypic changes in renal epithelia in vitro should contribute to a clearer understanding of complex biological processes such as organogenesis, regeneration, and carcinogenesis in epithelial organs such as the kidney.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk