[Synthesis and pharmacologic study of 1,5-benzodiazepine-2,4-dithiones and their alkyl derivatives]

A Zellou; Y Cherrah; E M Essassi; M Hassar

[Synthesis and pharmacologic study of 1,5-benzodiazepine-2,4-dithiones and their alkyl derivatives]

Ann Pharm Fr. 1998;56(4):175-80.

[Article in French]

Authors

A Zellou¹, Y Cherrah, E M Essassi, M Hassar

Affiliation

¹ Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Rabat Instituts, Maroc.

PMID: 9770011

Abstract

From the pharmacodynamic studies of 1,5-benzodiazepine-2,4-dithiones and alkyl derivatives, we can conclude that these products are not toxic at therapeutic dosage. They have sedative, myorelaxant and anxiolytic actions.

Publication types

English Abstract

MeSH terms

Alkylation
Animals
Anti-Anxiety Agents / chemical synthesis*
Anti-Anxiety Agents / pharmacology
Anti-Anxiety Agents / toxicity
Benzodiazepines
Hypnotics and Sedatives / chemical synthesis
Hypnotics and Sedatives / pharmacology
Mice
Muscle Relaxants, Central / chemical synthesis
Muscle Relaxants, Central / pharmacology
Rats
Rats, Wistar
Thiones / chemical synthesis*
Thiones / pharmacology
Thiones / toxicity

Substances

Anti-Anxiety Agents
Hypnotics and Sedatives
Muscle Relaxants, Central
Thiones
Benzodiazepines