J Mol Biol. 1998 Oct 23;283(2):435-49.

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.

Kallen J, Mikol V, Taylor P, Walkinshaw MD.

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The University of Edinburgh, Michael Swann Building, Edinburgh, EH9 3JR, UK.

Abstract

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.

PMID:: 9769216; [PubMed - indexed for MEDLINE]

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Cited by 5 PubMed Central articles

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Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
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Structures reported by this article

Human Cyclophilin A Complexed With 4 Meile Cyclosporin

PDB: 1CWM

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2 Å

See all 8 structures...

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X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.

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