Science. 1998 Oct 9;282(5387):298-300.

Transition from moderate to excessive drug intake: change in hedonic set point.

Source

Division of Psychopharmacology, Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. aserge@sage.scripps.edu

Abstract

Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.

PMID:: 9765157; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Cocaine

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Transition from moderate to excessive drug intake: change in hedonic set point.

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