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Ned Tijdschr Geneeskd. 1998 Jul 11;142(28):1618-21.

[Major psychiatric side effects of interferon alpha-2b].

[Article in Dutch]

Author information

  • 1Stichting Landelijke Registratie en Evaluatie Bijwerkingen (LAREB). MH's-Hertogenbosch.


The Netherlands Pharmacovigilance Foundation Lareb and the Drug Safety Unit of the Inspectorate for Health Care in 1997 received 6 reports of serious psychiatric symptoms during the use of interferon alpha-2b. Of these patients, three men aged 42, 49 and 62 years and three women aged 31, 40 and 33 years, two had had psychic symptoms before. Depression or psychosis developed 12-24 weeks after the start of the use of interferon alpha-2b with 3-10 million IU per week subcutaneously because of chronic hepatitis B or C. After cessation of the medication, four patients recovered after a few days or weeks; the course of one patient was unknown, one patient had committed suicide. Knowledge of these psychiatric adverse drug reactions to interferon alpha-2b can contribute to early recognition by the physician and timely treatment of the symptoms.

[PubMed - indexed for MEDLINE]
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