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    FEBS Lett. 1998 Sep 18;435(2-3):263-8.

    Cloning, expression, and localization of a novel gamma-adaptin-like molecule.

    Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I.

    Source

    Yale University School of Medicine, Department of Cell Biology, New Haven, CT 06520-8002, USA.

    Abstract

    We describe the cloning, expression, and localization of gamma2-adaptin, a novel isoform of gamma-adaptin. The predicted human and mouse gamma2-adaptin proteins are approximately 90 kDa and 64.4% and 61.7%) identical to gamma-adaptin, respectively. gamma2-Adaptin was localized to the Golgi, its localization distinct from gamma-adaptin. The membrane association of gamma- and gamma2-adaptin could further be distinguished by differential sensitivity to the fungal metabolite brefeldin A, gamma2-adaptin binding being insensitive to drug treatment. Together, these results suggest that gamma2-adaptin plays a role in membrane transport distinct from that played by gamma-adaptin.

    PMID:
    9762922
    [PubMed - indexed for MEDLINE]

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