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Annu Rev Biochem. 1998;67:753-91.

TGF-beta signal transduction.

Author information

  • Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. j-massague@ski.mskcc.org

Abstract

The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.

PMID:
9759503
[PubMed - indexed for MEDLINE]

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