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Biol Psychiatry. 1998 Sep 1;44(5):361-3.

MN blood groups and bipolar disorder: evidence of genotypic association and Hardy-Weinberg disequilibrium.

Author information

  • 1Department of Psychiatry, University of Ottawa, Ontario, Canada.

Abstract

BACKGROUND:

MN blood groups have been studied in the past as a genetic marker of biopolar disorder (BD). Several previous studies reported an association of the illness with lower frequency of blood group NN.

METHODS:

We analyzed distribution of MN blood groups in a sample of 174 patients with BD, 176 with unipolar depression, 98 with schizophrenia, and 331 healthy controls. In addition, we tested whether the inferred genotypes. conform to Hardy-Weinberg equilibrium (HWE).

RESULTS:

The frequency of NN phenotype was significantly lower among the bipolar patients than in any of the other three groups (p < .001). The genotype frequencies in the BD group deviated significantly from those expected under HWE (p < .01).

CONCLUSIONS:

These results suggest a possible locus on chromosome 4 (4q28-q31.1) associated with genetic susceptibility to bipolar illness.

PMID:
9755358
[PubMed - indexed for MEDLINE]
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