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Am J Med Genet. 2000 Feb 7;96(1):128-9.
Autistic symptoms among children and young adults with isodicentric chromosome 15.
Genetic Services, Elwyn Inc., Elwyn, Pennsylvania 19063, USA.
A standardized assessment of autistic symptomatology was completed for 29 children and young adults with a supernumerary isodicentric chromosome 15 (formerly known as inverted duplication 15). Although there was variability in severity, 20 individuals with an isodicentric chromosome 15 [idic(15)] had a high probability of being autistic. Eight of the 9 remaining children were under age 5 years and were more sociable than the rest of the cohort. Group characteristics such as gender and seizure presence could not explain the observed difference between older and younger individuals in our study. The natural history of isodicentric 15 syndrome remains to be shown through longitudinal work and may include an age-related risk for developing autism.
PMID: 9754629 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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ReviewThe inv dup (15) or idic (15) syndrome (Tetrasomy 15q).
Battaglia A.
Orphanet J Rare Dis. 2008 Nov 19; 3:30. Epub 2008 Nov 19.
[Orphanet J Rare Dis. 2008]
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Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder.
DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD.
Behav Brain Res. 2008 Mar 5; 187(2):207-20. Epub 2007 Sep 14.
[Behav Brain Res. 2008]
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Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes.
Shao Y, Cuccaro ML, Hauser ER, Raiford KL, Menold MM, Wolpert CM, Ravan SA, Elston L, Decena K, Donnelly SL, et al.
Am J Hum Genet. 2003 Mar; 72(3):539-48. Epub 2003 Feb 3.
[Am J Hum Genet. 2003]