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Bull Cancer. 1998 Jul;85(7):606-7.

[Histone deacetylase and retinoblastoma protein].

[Article in French]

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  • 1Laboratoire Oncogenèse, DiffĂ©renciation et Transduction du signal, CNRS UPR 9079, Villejuif.


The balance between cellular proliferation and differentiation is strictly controlled in the cell and the deregulation of this balance can lead to tumour formation. The tumour suppressor protein Rb plays a key role in this balance essentially by repressing progression through the cell cycle and thereby it blocks the cell in G1 phase. Rb represses S phase genes through the recruitment of an enzyme which modifies DNA structure, the histone deacetylase HDAC1. The Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation. Moreover, this complex is likely to be a target for transforming viral proteins.

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