Abstract
Bioactivity-directed fractionation of the leaves of Annona muricata L. (Annonaceae) resulted in the isolation of two new Annonaceous acetogenins, muricoreacin (1) and murihexocin C (2). Compounds 1 and 2 showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarcinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Adenocarcinoma / drug therapy
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Chromatography, High Pressure Liquid
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / pharmacology
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Furans / isolation & purification*
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Furans / pharmacology*
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Humans
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Magnetic Resonance Spectroscopy / methods
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Male
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Pancreatic Neoplasms / drug therapy
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology*
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Prostatic Neoplasms / drug therapy
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Spectrometry, Mass, Fast Atom Bombardment
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Trees / chemistry
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Fatty Alcohols
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Furans
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Lactones
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Plant Extracts
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isomurisolenin
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muricoreacin
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murihexocin C
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4-Butyrolactone