Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1998 Sep 18;281(5384):1860-3.

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

Author information

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.

Abstract

The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.

PMID:
9743501
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk