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J Control Release. 1998 Apr 30;53(1-3):49-67.

Delivery of molecular and cellular medicine to solid tumors.

Author information

  • Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. jain@steele.mgh.harvard.edu

Abstract

To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

PMID:
9741913
[PubMed - indexed for MEDLINE]
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