Planta Med. 1998 Aug;64(6):500-3.

In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria.

Lee BH, Lee SJ, Hur JH, Lee S, Sung JH, Huh JD, Moon CK.

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College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Korea. bhlee@wonnms.wonkwang.ac.kr

Erratum in

Planta Med 1998 Dec;64(8):769. Hui JH [corrected to Hur JH].

Abstract

Ginseng saponin metabolites produced by human intestinal bacteria were evaluated for antigenotoxic properties by testing their effects on benzo[a]pyrene (B[a]P)-induced mutagenicity and clastogenicity. They include 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), 20-O-(alpha-D-arabinopyranosyl(1-->6)-beta-D-glucopyranosyl]- 20(S)-protopanaxadiol (IH-902) and 20-O-[alpha-D-arabinofuranosyl(1-->6)-beta-D-glucopyranosyl]-20(S)- protopanaxadiol (IH-903). IH-901, IH-902 and IH-903 inhibited the mutagenicity of B[a]P in a dose-dependent manner. In the chromosome aberration assay, IH-901 and IH-903 reduced the frequency of chromosome aberration induced by B[a]P. These results suggest that the ginseng saponin metabolites tested in the present study have potential as chemopreventive agents.

PMID:: 9741293; [PubMed - indexed for MEDLINE]

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