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Biochim Biophys Acta. 1998 Aug 19;1378(1):F1-19.

The papillomavirus E6 proteins.

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  • 1Department of Dermatology, New England Medical Center, Boston, MA, USA.

Abstract

Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.

PMID:
9739758
[PubMed - indexed for MEDLINE]
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