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Antimicrob Agents Chemother. 1998 Sep;42(9):2456-8.

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives.

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  • 1Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.

Abstract

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

PMID:
9736585
[PubMed - indexed for MEDLINE]
PMCID:
PMC105855
Free PMC Article
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