Nutr Rev. 1998 Aug;56(8):236-44.

Open or closed? A world of difference: a history of homocysteine research.

Source

University Hospital Nijmegen, The Netherlands.

Erratum in

Nutr Rev 1998 Oct;56(10):313.

Abstract

This article presents the research of the Nijmegen homocysteine team on birth defects and vascular disease. Hyperhomocysteinemia was found in women who gave birth to offspring with neural tube defects (NTDs) and other birth defects and in women with vascular disease. Elevated homocysteine levels in the blood plasma can be explained by lack of B vitamins (folic acid), mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) genes, or both. Genetic mutations were found on the first chromosome (677 C T and 1298 A-C) and can explain up to 50% of the protective effect of folic acid against NTDs. The inborn error of methionine-homocysteine metabolism was also found in cases with recurrent early pregnancy loss, schisis, congenital heart defects, and vascular problems such as placental abruption, infarcts, and fetal growth retardation. One of the most exciting medical findings of recent years is that folic acid can prevent NTDs. This might also hold true for other birth defects and vascular disease.

PMID:: 9735677; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

FOLIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review From birth to conception. Open or closed. [Eur J Obstet Gynecol Reprod Bi...]
Review From birth to conception. Open or closed.
Eskes TK. Eur J Obstet Gynecol Reprod Biol. 1998 Jun; 78(2):169-77.
Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense? [Genet Test. 2002]
Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?
Finnell RH, Shaw GM, Lammer EJ, Volcik KA. Genet Test. 2002 Spring; 6(1):47-52.
Review Neural tube defects, vitamins and homocysteine. [Eur J Pediatr. 1998]
Review Neural tube defects, vitamins and homocysteine.
Eskes TK. Eur J Pediatr. 1998 Apr; 157 Suppl 2:S139-41.
Review Folate, homocysteine and neural tube defects: an overview. [Exp Biol Med (Maywood). 2001]
Review Folate, homocysteine and neural tube defects: an overview.
van der Put NM, van Straaten HW, Trijbels FJ, Blom HJ. Exp Biol Med (Maywood). 2001 Apr; 226(4):243-70.
Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. [Am J Med Genet A. 2008]
Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.
Candito M, Rivet R, Herbeth B, Boisson C, Rudigoz RC, Luton D, Journel H, Oury JF, Roux F, Saura R, et al. Am J Med Genet A. 2008 May 1; 146A(9):1128-33.

See reviews... See all...

Cited by 1 PubMed Central article

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil. [Nutr J. 2011]
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil.
Siqueira ER, Oliveira CP, Muniz MT, Silva F, Pereira LM, Carrilho FJ. Nutr J. 2011 Aug 19; 10:86. Epub 2011 Aug 19.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Open or closed? A world of difference: a history of homocysteine research.
Open or closed? A world of difference: a history of homocysteine research.
Nutr Rev. 1998 Aug ;56(8):236-44.

PubMed
The NMR structure of estrone (Es)-tethered tandem DNA duplex: [d(5'pCAGCp3')-Es]...
The NMR structure of estrone (Es)-tethered tandem DNA duplex: [d(5'pCAGCp3')-Es] + [Es-d(5'pTCCA3')]: d(5'pTGGAGCTG3').
J Biomol Struct Dyn. 1997 Dec ;15(3):499-516.

PubMed
The influence of suction catheter tip design on tracheobronchial trauma and flui...
The influence of suction catheter tip design on tracheobronchial trauma and fluid aspiration efficiency.
Anesth Analg. 1976 Mar-Apr ;55(2):290-7.

PubMed
Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggr...
Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: implications for stress-induced suppression of protein synthesis.
Brain Res. 1997 Nov 14 ;775(1-2):43-51.

PubMed
A potential ignition source in the operating room.
A potential ignition source in the operating room.
Anesth Analg. 1976 Mar-Apr ;55(2):217-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Open or closed? A world of difference: a history of homocysteine research.

Source

Erratum in

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information