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Surg Oncol Clin N Am. 1998 Oct;7(4):845-61.

Gastrinoma: advances in localization and treatment.

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  • 1University of California at San Francisco; San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.


Gastrinomas secrete gastrin and cause symptoms related to gastric acid hypersecretion that can be controlled by antisecretory medications. Primary tumors are located within the pancreas or duodenum and 60% metastasize. Liver metastases are associated with decreased survival. Localization studies especially somatostatin receptor scintigraphy are indicated to image the extent of disease. Surgery is indicated to potentially cure the patient, or control the malignant tumoral process and prolong survival.

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