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Brain Res. 1998 Aug 10;801(1-2):251-3.

Self-sustaining status epilepticus after brief electrical stimulation of the perforant path.

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  • 1Veteran Administration Medical Center, Neurology Service, UCLA School of Medicine, Sepulveda, USA. mazarati@ucla.edu


We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-sustaining status epilepticus (SSSE) in rats. Seven-minute PPS did not induce SSSE. Some rats receiving 15 min and all animals after 30 min PPS developed SSSE that continued for hours. The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures.

Copyright 1998 Elsevier Science B.V.

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