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Trends Cell Biol. 1998 Sep;8(9):353-8.

Vertebrate photoreceptor cell development and disease.

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  • 1Dept of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.


Photoreceptors provide an excellent model for studies of vertebrate neuronal differentiation, and many human diseases resulting in blindness primarily affect photoreceptors. There is therefore great interest in studying the cellular and molecular mechanisms of photoreceptor development. This article discusses our current understanding of this process, including the recent discovery of the homeodomain transcription factor Crx and its potential role in diseases affecting human vision.

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