Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10734-9.

Increased anxiety of mice lacking the serotonin1A receptor.

Parks CL, Robinson PS, Sibille E, Shenk T, Toth M.

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Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.

Abstract

Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.

PMID:: 9724773; [PubMed - indexed for MEDLINE]
PMCID:: PMC27964

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