Tubulin and FtsZ structures: functional and therap...[Bioessays. 1998]

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1: Bioessays. 1998 Jul;20(7):523-7. Links

Tubulin and FtsZ structures: functional and therapeutic implications.

Desai A, Mitchison TJ.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Arshad_Desai@hms.harvard.edu

The microtubule cytoskeleton has lagged nearly a decade behind the actin cytoskeleton with respect to structural information on the basic polymer subunit. This structural inferiority complex has finally been lifted by two recent papers describing the structures of the alpha beta tubulin dimer and FtsZ, a protein similar to tubulin that is essential for cell division in prokaryotes.

PMID: 9722999 [PubMed - indexed for MEDLINE]

The polymerization mechanism of the bacterial cell division protein FtsZ. [FEBS Lett. 2001]
Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers. [Proc Natl Acad Sci U S A. 1996]
Bacterial ancestry of actin and tubulin. [Curr Opin Microbiol. 2001]
A dynamic bacterial cytoskeleton. [Trends Cell Biol. 2003]
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives. [Curr Opin Struct Biol. 2006]
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Tubulin and FtsZ structures: functional and therapeutic implications.

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