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Curr Opin Immunol. 1998 Aug;10(4):382-7.

HIV-2 and T cell recognition.

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  • 1MRC Laboratories, The Gambia, West Africa.


HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-2 infection than in HIV-1 infection. These insights may be crucial to the design of effective vaccines.

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