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KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels.
Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan.
Cerebellar granule neurons possess a non-inactivating K+ current, which controls resting membrane potentials and modulates the firing rate by means of muscarinic agonists. kcr1 was cloned from the cerebellar cDNA library by suppression cloning. KCR1 is a novel protein with 12 putative transmembrane domains and enhances the functional expression of the cerebellar non-inactivating K+ current in Xenopus oocytes. KCR1 also accelerates the activation of rat EAG K+ channels expressed in Xenopus oocytes or in COS-7 cells. Far-Western blotting revealed that KCR1 and EAG proteins interacted with each other by means of their C-terminal regions. These results suggest that KCR1 is the regulatory component of non-inactivating K+ channels.
PMID: 9722534 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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K+ channel regulator KCR1 suppresses heart rhythm by modulating the pacemaker current If.
Michels G, Er F, Khan IF, Endres-Becker J, Brandt MC, Gassanov N, Johns DC, Hoppe UC.
PLoS One. 2008 Jan 30; 3(1):e1511. Epub 2008 Jan 30.
[PLoS One. 2008]
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In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR.
Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11773-8. Epub 2004 Jul 27.
[Proc Natl Acad Sci U S A. 2004]
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A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
Millar JA, Barratt L, Southan AP, Page KM, Fyffe RE, Robertson B, Mathie A.
Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3614-8.
[Proc Natl Acad Sci U S A. 2000]
Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...