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Tramadol hydrochloride: an overview of current use.
St. Bartholomew's, London.
Tramadol's two enantiomers produce analgesia, in acute and chronic pain states, by combining synergistically, weak opioid and monoaminergically-mediated mechanisms. Tramadol is interesting, being free of some of the clinically significant side-effects seen with other opioids of comparable efficacy.
PMID: 9722388 [PubMed - indexed for MEDLINE]
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