-
Tramadol hydrochloride: an overview of current use.
St. Bartholomew's, London.
Tramadol's two enantiomers produce analgesia, in acute and chronic pain states, by combining synergistically, weak opioid and monoaminergically-mediated mechanisms. Tramadol is interesting, being free of some of the clinically significant side-effects seen with other opioids of comparable efficacy.
PMID: 9722388 [PubMed - indexed for MEDLINE]
-
Cited by 3 PubMed Central articles
-
The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms.
Herbert MK, Weis R, Holzer P.
BMC Pharmacol. 2007 Mar 16; 7:5. Epub 2007 Mar 16.
[BMC Pharmacol. 2007]
-
Pharmacokinetic evaluation of a new oral sustained release dosage form of tramadol.
Malonne H, Sonet B, Streel B, Lebrun S, De Niet S, Sereno A, Vanderbist F.
Br J Clin Pharmacol. 2004 Mar; 57(3):270-8.
[Br J Clin Pharmacol. 2004]
-
Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.
Potschka H, Friderichs E, Löscher W.
Br J Pharmacol. 2000 Sep; 131(2):203-12.
[Br J Pharmacol. 2000]