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    Science. 1998 Aug 28;281(5381):1305-8.

    Death receptors: signaling and modulation.

    Ashkenazi A, Dixit VM.

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    Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. aa@gene.com

    Abstract

    Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

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    PMID:
    9721089
    [PubMed - indexed for MEDLINE]

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