J Nerv Ment Dis. 1998 Aug;186(8):500-1.

Is St. John's wort (Hypericum perforatum) an effective antidepressant?

Source

Adult Psychopharmacology Program, National Institute of Mental Health, Rockville, Maryland 20857, USA.

Abstract

SJW is a remarkably safe antidepressant with an apparently unique mode of action. Although it has demonstrated efficacy in mild and moderate depression when compared with placebo or tricyclic antidepressants, several research areas beg to be explored. Its effects should be compared with serotonin reuptake inhibitors. Studies in severely depressed patients are lacking, as are studies on its utility as a therapeutic adjunct to standard antidepressants.

PMID:: 9717868; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Antidepressants - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

St John's wort for depression--an overview and meta-analysis of randomised clinical trials. [BMJ. 1996]
St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. BMJ. 1996 Aug 3; 313(7052):253-8.
St John's wort as an antidepressant. [BMJ. 1996]
St John's wort as an antidepressant.
De Smet PA, Nolen WA. BMJ. 1996 Aug 3; 313(7052):241-2.
Review St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions. [Altern Med Rev. 1998]
Review St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions.
Miller AL. Altern Med Rev. 1998 Feb; 3(1):18-26.
Should you take St. John's Wort? [Health News. 1998]
Should you take St. John's Wort?
Nierenberg A. Health News. 1998 Apr 20; 4(5):4-5.
Review Controlled clinical trials of hypericum extracts in depressed patients--an overview. [Pharmacopsychiatry. 1997]
Review Controlled clinical trials of hypericum extracts in depressed patients--an overview.
Volz HP. Pharmacopsychiatry. 1997 Sep; 30 Suppl 2:72-6.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Herb-drug interactions: review and assessment of report reliability. [Br J Clin Pharmacol. 2001]
Review Herb-drug interactions: review and assessment of report reliability.
Fugh-Berman A, Ernst E. Br J Clin Pharmacol. 2001 Nov; 52(5):587-95.
Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection. [Antimicrob Agents Chemother. 2...]
Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection.
Jacobson JM, Feinman L, Liebes L, Ostrow N, Koslowski V, Tobia A, Cabana BE, Lee D, Spritzler J, Prince AM. Antimicrob Agents Chemother. 2001 Feb; 45(2):517-24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Is St. John's wort (Hypericum perforatum) an effective antidepressant?
Is St. John's wort (Hypericum perforatum) an effective antidepressant?
J Nerv Ment Dis. 1998 Aug ;186(8):500-1.

PubMed
Additional modules for versatile and economical PCR-based gene deletion and modi...
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae.
Yeast. 1998 Jul ;14(10):953-61.

PubMed
Heterologous modules for efficient and versatile PCR-based gene targeting in Sch...
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe.
Yeast. 1998 Jul ;14(10):943-51.

PubMed
Global climate change and infectious diseases.
Global climate change and infectious diseases.
Emerg Infect Dis. 1998 Jul-Sep ;4(3):451-2.

PubMed
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncoge...
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.
Genes Dev. 1998 Aug 15 ;12(16):2469-74.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Is St. John's wort (Hypericum perforatum) an effective antidepressant?

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information