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South Med J. 1998 Aug;91(8):739-44.

Gabapentin for treatment of pain and tremor: a large case series.

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  • 1Neurology Clinic of San Antonio, TX 78229, USA.

Abstract

BACKGROUND:

Several anticonvulsant agents, including carbamazepine, phenytoin, and valproate, are effective in some patients for the treatment of pain and tremor. This study reports on a trial of the newly introduced anticonvulsant, gabapentin, for pain and tremor control.

METHODS:

A large case series of patients with centrally mediated pain, peripherally mediated pain, migraine, and tremor were treated in an open-label study with gabapentin (maximum of 2,700 mg/day).

RESULTS:

Thirty-nine patients (65%) had moderate-to-excellent improvement in symptoms, with the best responses occurring in patients with peripherally mediated neuropathic pain. The other conditions treated that showed some improvement were benign essential/familial tremor, restless legs syndrome, centrally mediated pain, and periodic nighttime leg movements.

CONCLUSIONS:

Gabapentin offers an effective, safe alternative therapy or co-therapy for the listed painful conditions and tremor; it does not affect the metabolism of other medications and is well tolerated.

PMID:
9715219
[PubMed - indexed for MEDLINE]
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