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FEBS Lett. 1998 Jul 24;431(3):468-72.

Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11.

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  • 1Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.

Abstract

We cloned a human PEX11 cDNA by expressed sequence tag homology search using yeast Candida boidinii PEX11, followed by screening of human liver cDNA library. PEX11 encoded a peroxisomal protein Pex11p comprising 247 amino acids, with two transmembrane segments and a dilysine motif at the C-terminus. Pex11p comigrated in SDS-PAGE with a 28-kDa peroxisomal integral membrane protein (PMP28) isolated from the liver of clofibrate-treated rats and was crossreactive to anti-PMP28 antibody, thereby indicating PEX11 to encode PMP28. Pex11p exposes both N- and C-terminal parts to the cytosol. PEX11 was not responsible for ten complementation groups of human peroxisome deficiency disorders.

PMID:
9714566
[PubMed - indexed for MEDLINE]
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